To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.
The Cellular Metabolism group is led by Associate Professor Erik Norberg at the Dept. of Physiology and Pharmacology.
The group has a central focus on profiling and understanding how the cancer metabolism is altered through cancer development, with the ultimate goal to identify new disease drivers, diagnostic tool as well as therapeutic targets. We employ modern omics methods on normal cells, cancer cell lines, mouse models and human cancer biopsies.
The group is located in an inspiring and interactive research environment in the top modern Biomedicum at Campus Solna and has on-going collaborative projects with national and international colleagues from academia and the biotech industry. More info about the group, please visit our web page: https://ki.se/en/fyfa/the-erik-norberg-lab-cellular-metabolism
A cancer cell’s metabolism is very distinct from the normal cell it originates from. This rewiring of metabolism occurs because rapidly proliferating cells needs to generate new biomass to build a new cell.
The goal of this doctoral project is to identify new factors that are critical to drive non-small cell lung cancer (NSCLC) development and progression. The specific aim is to define differential gene expression patterns and to identify which metabolic states exists across NSCLC pathogenesis. Thus, the work will involve biopsy collection in the hospital and sample preparation for metabolomics, genomics and transcriptomics approaches, analysis of data, bioinformatics on the obtained data. Once this is established, validation and targeting of identified metabolic signatures/nodes will be experimentally tested in cell lines and mouse models.
The student is expected to take the mandatory PhD courses of the doctoral program, actively participate in regular group meetings, seminars, present their work at national/international meetings and take part in routine work within the research team. Importantly, the student is expected to plan and drive the research projects, perform experiments, analyze and interpret data, and present results as posters, in seminars/conferences and as research articles.
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.
It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.
A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:
Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.
*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.
B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:
- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.
Follow the instructions on the web page English language requirements for doctoral education.
Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.
(A) and (B) can only be certified by the documentation requirement for doctoral education.
We are looking for a highly motivated and enthusiastic candidate that expresses a passionate research interest in the research aims of the lab.
The candidate should be able to work efficiently with the research team but also be self-driven to conduct independent duties to drive the project.
For this project it is desired that the applicant has a background and hands-on research experience in standard biochemical and molecular biological techniques beyond culturing of mammalian cells. Since the work will involve animal work, it is desired if the candidate has experience with animal work or at least be willing to master this.
The candidate must be fluent in English and have excellent writing skills. The candidate will join an enthusiastic, collaborative, hardworking and dynamic team.
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time. Intended start date Sept/Oct 2023.
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.
Your application must contain the following documents:
- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.
Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.
All applicants will be informed when the recruitment is completed.
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