We are looking for a motivated PhD student to join our team, with a start date in late 2026 or early 2027.

The Laboratory of Toxicology in the ETH at the Department of Health Sciences and Technology is looking for a new PhD student with a focus on genomic biomarkers of health and disease.

We strive to understand biochemical and cellular mechanisms governing bioactive properties of chemicals in order to promote food, drug and personal care product function and safety. Researchers develop and apply quantitative chemical, in vitro, and computational approaches to address problems in Toxicology. 

We develop and apply bioanalysis approaches to map DNA damage at single-base resolution. Building on these newly established tools, we integrate complementary multi-omic approaches to characterize DNA damage in the context of genome organization and function. Through application of these methods to clinically relevant biological material, we aim to mechanistically dissect the role of DNA damage in aging and disease.

A PhD position is available concerning UV-induced skin aging and enabling biomarker technologies for prevention. The group addresses mechanisms of genome instability of diverse physical and chemical exposures, such as from the environment, lifestyle factors and drugs, as well as cellular metabolism and oxidative stress. In this PhD project, you will expand this research to uncover biomarkers of aging, a process driven by DNA damage. You will use DNA sequencing and related methods to characterize cellular responses to stress and following interventions. Using bioinformatics, these data will be integrated with characteristics such as gene expression and DNA methylation. 

A successful applicant will have, or expect to obtain before starting, an MSc or equivalent in Chemistry, Chemical Biology, Toxicology, Pharmaceutical Sciences, Food Science, Molecular Biology, Microbiology, or a closely related discipline. Good written and oral communication skills in English are needed. The individual should have a self-dependent mindset, good leadership qualities, and a strong foundation of practical relevant laboratory experience. Bioinformatics skills are beneficial but can be expanded during the PhD. Students who excel in the chemical biology of nucleic acids, genomic sequencing, in vitro toxicology, or related topics are particularly encouraged to apply.

• Your job with impact: Become part of ETH Zurich, which not only supports your professional development, but also actively contributes to positive change in society
• You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports offered by the ASVZ, childcare and attractive pension benefits

We look forward to receiving your online application with the following documents:

• Motivational Letter
• Detailed CV 
• Transcripts of all degrees (English)
• Master Diploma
• Contact details of 2 references

Further information about the Laboratory of Toxicology can be found on our Website. Questions regarding the position should be directed to the following e-mail adress, [email protected] (no applications).

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.