The Center for Entrepreneurship and Innovation (CEI) within Skoltech provides education, research, and administrative functions related to the practice of entrepreneurship and innovation, spanning across and coupled to the degree-granting Programs. Fifteen Centers for Research, Education and Innovation (CREIs) will be associated with Skoltech, each residing under one or more of the programs. Each CREI will have a thematic research mission carried out through a distributed collaborative research program between Skoltech, international, and Russian institutions, and will have both physical and virtual components. As the Skoltech campus and research laboratories are constructed and equiped, Skoltech faculty, staff and students will conduct their research under each CREI in new physical laboratories at Skoltech. In addition, each CREI will have a virtual component, comprised of ongoing research collaborations with and between the CREI partner institutions in which each institution’s researchers conduct their research primarily at their home facilities, but in thematic and intellectual collaboration across and within CREIareas and projects. Finally, Skoltech will have central administration that provides the educational and research facilities and services of a modern research university. In the fall 2012, Skoltech accepted 20 Master’s degree students into its first class for programs in Energy Science and Technology and Information Science and Technology. After a unique pilot program 45 new M.Sc. students from Russia and around the world joined them for three programs in Information Science and Technology, Energy Science and Technology, and Biomedicine Science and Technology.