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Wellcome Sanger Institute

Technical Specialist | Generative and Synthetic Genomics

2025-02-23 (Europe/London)
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Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.

We have an exciting opportunity for a Technical Specialist to join the Taipale group in the Generative and Synthetic Genomics Programme at the Wellcome Sanger Institute.

About the Role

As Technical Specialist, you will be responsible for:

  • Operating and maintaining automated pipelines and enhancing workflows
  • Development of technologies and methods for the study of gene expression using genomics and computational approaches, for example setting up advanced methods for parallel genomic integration of large DNA payloads
  • Collaborating with internal teams and external collaborators to ensure project progress and provide regular updates

About Us

The Taipale group is newly established at the Wellcome Sanger Institute. 

The laboratory consists of experimental biologists and computer scientists who focus on the study of transcriptional control of cell growth, using functional genomics and systems biology, and mouse genetic models. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, and using this information to identify regulatory elements that control cell growth during normal development and in cancer (see, for example Hallikas et al., Cell 124:47-59, 2006; Sur et al., Science 338:1360-1363, 2012; Jolma et al., Cell 152:327-339, 2013; Jolma et al., Nature 527:384-388, 2015; Yin et al., Science 356:eaaj2239, 2017; Zhu et al., Nature 562:76-81, 2018; Yan et al., Nature 591:147-151, 2021; Sahu et al., Nature Genetics 54:283–294, 2022).

The lab benefits from access to cutting-edge facilities at the Wellcome Sanger Institute such as DNA sequencing, Cell Operations and Automation.

We aim to decipher the regulatory genetic code using random DNA and measuring its activity using experimental and AI models (see Nature 625, 41–50, 2024). The work profile will be a combination of wet-lab and dry-lab tasks.

About You

To excel in this role, you will need the following skills and experience:

  • A degree in Biochemistry, Biology, Chemistry or related discipline. A PhD or post-graduate degree in a related discipline would be desirable.
  • A background in genomics, biophysics or a related discipline and a desire to perform quantitative experiments at scale to address fundamental questions in molecular biology.
  • Using liquid handler platforms with Beckman/Hamilton being an advantage.
  • Excellent communication skills and the ability to communicate effectively with stakeholders.

Other Information:

Please include a cover letter along with your CV. In your cover letter, include detail on how your knowledge, skills and experience match the requirements of the role described.

Salary: £40,500 - £48,600

Closing date: Sunday 23-FEB

Contract length: Permanent

View the full role profile here.

Hybrid Working at Wellcome Sanger:

We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity and Inclusion:

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Our Benefits:

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018.  The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.

Every year the Wellcome Sanger Institute supports the visits of dozens of overseas researchers from across the globe to the Genome campus to collaborate, share insights and to undertake ground-breaking scientific research. Our reliable in-house service provides expert advice and guidance to support current and prospective staff, and visitors at various points of their journey. We are able to provide guidance through your entire journey, from initial visa application through to extensions and applications of Indefinite Leave to Remain, the service is proud to support your personal applications and those of your dependants and family members. 

For more information about our immigration service visit: https://www.sanger.ac.uk/about/careers/global-mobility-and-immigration-service/ 

Job details

Title
Technical Specialist | Generative and Synthetic Genomics
Location
Wellcome Trust Genome Campus, Hinxton Saffron Walden, United Kingdom
Published
2025-02-04
Application deadline
2025-02-23 23:59 (Europe/London)
2025-02-24 00:59 (CET)
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About the employer

We are a world-leading genomics research institute. Our work helps improve human health and understand life on Earth.

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