The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors.
The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary and together we contribute to science and society.
The University of Luxembourg has the following vacancy at the Luxembourg Centre for Systems Biomedicine (LCSB) - Molecular & Functional Neurobiology group:Research & Development Specialist
Successful candidates will join the Molecular & Functional Neurobiology group, led by Prof. Anne Grünewald, which studies the genetic and non-genetic causes of neurodegeneration and neuroinflammation in Parkinson’s disease. Specifically, the group explores the contribution of intra- and intercellular mitochondrial signaling to these processes. For more information, please visit our website.
The R&D specialist will support the implementation of various projects, including “CAMeSyn”, which explores the metabolic dependencies of neurons and astrocytes in Parkinson’s disease, and “ProtectMove II”, in which we investigate the crosstalk between environment and genetics in the pathogenesis of PD.
Your Role...
- Generation/maintenance of induced pluripotent stem cells and subsequent differentiation into neurons, microglia and astrocytes
- Study of cellular intermediary metabolism (LC- and GC-based methods)
- Assessment of cellular and mitochondrial function using advanced imaging techniques and molecular biology methods (including RNA-seq)
- Data analysis, data interpretation and reporting of results
- Participate in knowledge dissemination activities through the preparation of scientific publications or presentations in scientific venues
- Participate in funding applications (support hypothesis generation, conception, and grant writing)
- Participate in teaching activities (seminars and practicals)
- Support and tutoring of activity of students
What we expect from you…
- MSc in Life Sciences, Neurosciences, Molecular Biology or related field with solid lab experience (+5 years)
- Strong interest in interdisciplinary research and cellular models of neurodegeneration
- Proven experience (+5 years) in human induced pluripotent stem cell technologies, with solid knowledge in neuronal and glial differentiation protocols
- Good command of molecular biology methods
- Experience in RNA-seq analysis is considered an advantage
- Knowledge in intermediary metabolism and application of 13C-Isotope assisted metabolomics
- Experience with high-content image analysis and subsequent data handling (coding skills in MATLAB and/or R are considered as assets)
- Skills to autonomously conduct data analysis with solid understanding of statistics
- Excellent written and oral communication skills in English with proven experience in the writing of grants and scientific publications
- Excellent team-working, interpersonal skills, and ability to collaborate with local and international partners
- Enthusiasm and commitment to research
- Ability to think ahead as well as to troubleshoot
Here’s what awaits you at the LCSB...
- Excellent work environment with state-of-the-art infrastructure, laboratory and administrative support
- Truly connected. We work together with hospitals and research institutes on a national and international level as well as industrial partners. Connection between science and society is very important to us. From our school lab – the Scienteens Lab – to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society’s needs and share our passion for science
- Be part of a multicultural team. At the LCSB we have more than 50 nationalities. Throughout the year, we organise team-building events, networking activities and more
In Short...
- Contract type: Contrat à durée indéterminée
- Work hours: Full Time 40.0 Heures par Semaine
- Location: Belval
- Internal title: Research and development specialist
- Job reference: UOL05629
How to apply...
Applications should be submitted online and include:
- Detailed Curriculum Vitae including a list of publications
- Cover letter mentioning the reference number
- Copies of diploma and transcripts
- Name and addresses of three referees
Early application is highly encouraged, as the applications will be processed upon reception. Please apply formally through the HR system. Applications by email will not be considered.
The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff.
About the University of Luxembourg...
University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and has more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres focus on researchin the areas of Computer Science and ICT Security, Materials Science, European and International Law, Finance and Financial Innovation, Education, Contemporary and Digital History. In addition, the University focuses on cross-disciplinary researchin the areas of Data Modelling and Simulation as well as Health and System Biomedicine. Times Higher Education ranks the University of Luxembourg #3 worldwide for its “international outlook,” #20 in the Young University Ranking 2021 and among the top 250 universities worldwide.
Further information
For further information, please contact Prof. A. Grünewald at anne.gruenewald@uni.lu. Use the job title and reference number mentioned above in the subject line of your email.
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