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The Department of Antwerp Surgical Training, Anatomy and Research Centre in the Faculty of Medicine and Health Sciences is looking for a full-time doctoral scholarship holder in the field of novel surgical approaches for lung cancer
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Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Patients with advanced lung cancer are treated with chemotherapy and/or immunotherapy. We and others have demonstrated that isolated lung perfusion (ILuP) is a technique that is able to deliver high doses of chemotherapy specifically to the lung by using a closed lung bypass circuit but with minimal systemic exposure. This was also confirmed in phase I and phase II clinical trials by our group in which surgical resection was combined with ILuP. With this new project which is sponsored by 'Kom op tegen kanker', we want to further improve this technology as a repetitive endovascular technique in preparation for new human clinical trials. To this end, a series of porcine, and humane ex-vivo experiments will be performed to assess the optimal dose and conditions to selectively administer chemotherapy to the lung alone. A cutting-edge surgical model will therefore be optimized and combined with molecular and imaging tools such as CT, microCT, histopathology, RT-PCR and mass spectrometry.
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