A postdoctoral fellow position is available in the Department of Molecular Genetics at the University of Kaiserslautern, Germany.
The primary scientific interest of our group is the maintenance of genome integrity and cellular responses to its disruption, with an emphasis on whole chromosome aneuploidy and polyploidy, as well as structural chromosomal rearrangements. We are particularly interested in understanding the consequences of chromosome copy number changes and how they affect cancer development. Specifically, our group has developed unique model systems of human cell lines with defined chromosomal changes that mimic the changes observed in cancer. We use molecular cell biology approaches as well as transcriptomics and proteomics to characterize how human cells adapt to abnormal chromosomal numbers.
The candidate will explore how human cells adapt to changes in chromosomal content and how these adaptations contribute to cancer. The use of molecular cell biology and tissue culture techniques such as CRISPR-Cas9 library screens, generation of engineered cells with abnormal chromosomes, or quantitative fluorescence imaging will be essential for this project. Additionally, the candidate will use various –omics approaches, including proteomics.
Interested applicants should have a PhD degree in Biology, Biotechnology, Genetics, Biochemistry, Bioinformatics or an equivalent field as well as a background in molecular cell biology techniques. Ideally, these will include experience with mammalian cell culture, gene delivery by retro or lentiviruses, PCR, qPCR, immunostaining, Western blot and FACS analysis. Experience in bioinformatics is welcome, but not essential. Prospective candidates will be part of an international, highly collaborative research team and expected to be highly motivated and passionate about science.
Biology Department of TU Kaiserslautern
University of Kaiserslautern is the only technology institute in Rheinland-Palatinate, Germany, specializing in linking the science with technology. Our Biology department is highly international, promoting independent thinking and excellence in small research groups, fostering a close contact among a variety of research fields and across hierarchies.
We look forward to receiving your online application with a full CV, motivation letter and names of at least two references. Please, submit the application Ingeborg Kluge (email@example.com). Application review will begin in January, 2020 and continue until the position is filled.
Further information about our group can be found at www.bio.uni-kl.de/molekulargenetik/.Continue reading
|Title||Postdoctoral Position in Aneuploidy in Human Cells and Its Contribution to Cancer|
|Employer||University of Kaiserslautern|
|Job location||Gottlieb-Daimler-Straße 47, 67663 Kaiserslautern|
|Published||January 8, 2020|
|Job types||Postdoc  |
|Fields||Biotechnology,   Cancer Research,   Biochemistry,   Bioinformatics,   Molecular Biology,   Genetics,   Cell Biology  |