Royal Veterinary College

Postdoctoral Research Assistant - Fixed Term (30 months) - Comparative Biomedical Sciences

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Location: Camden (King's Cross, London)

Salary: £35,802 to £39,997 Per Annum Including London Weighting

Fixed Term / Full Time

Closing Date: 05/12/2021

Interview Date: To be confirmed

Reference: CBS-0121-21

This is a fixed term contract for 30 months, with a possibility to extend up to a total of 36 months.

Topic: Developing personalised medicine for CLN3 disease

Job summary

Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), a paediatric progressive neurodegenerative disease is predominantly caused by a mutation that causes novel transcripts and this appears to result in new function. In this project, you will model this and other mutations in zebrafish, aiming to create and validate disease models that can be used for developing personalised therapies.


The post is full time and the successful applicant will be responsible for running the experimental program outlined in the awarded grant. We will use gene editing, antisense morpholino and mRNA injection to create the desired zebrafish disease model, with validation as a disease model via transcript and phenotypic analysis.

The Collaboration

The project will be supervised by Dr Claire Russell (RVC) with collaborators Prof Jason Rihel (UCL) and Dr Anselm Zdebik (UCL). Training will be provided by the supervisor, colllaborators or members of their teams. The post is funded by the Medical Research Council led by Prof Sara Mole at UCL and is part of a larger project that will identify CLN3 transcripts in patients and investigate the function of CLN3 protein from normal and abnormal transcripts using cells and yeast.

Due to the collaborative nature of the project, you are likely to spend time working in one or more UCL locations as well as the RVC.


Within the RVC, the Department of Comparative Biomedical Sciences (headed by Prof Caroline Wheeler‐Jones) consists of about 40 academic staff. Research activities cover various basic science disciplines including molecular biology, genetics, development, neurobiology, cellular biology, pharmacology, anatomy, physiology, biochemistry and locomotion. Your research is within the Brain Health and Behaviour group (led by Dr Claire Russell) within the Comparative Physiology and Clinical Sciences Research Programme (led by Prof Dominic Wells). Funding for the Department’s research is obtained from the Research Councils, various charitable organisations and industry.

Your profile

Applicants must have a PhD in a biological science or equivalent, and experience using zebrafish and gene editing. Equally desirable qualities are the ability to troubleshoot and optimise experiments, good organisational skills and record‐keeping, effective teamwork and excellent communication skills, with a high degree of motivation. You will be expected to perform risk assessment and follow health and safety rules. The degree of experience required means it is likely that the successful candidate will have already held a postdoctoral position.

Informal enquiries to Dr Claire Russell crussell@rvc.ac.uk

We offer a generous reward package including a pension scheme.

The RVC values diversity and is committed to the equality of opportunity. Balancing both the needs of the business with those of our staff, we will consider applications to work on a flexible basis where possible.

Job details

Postdoctoral Research Assistant - Fixed Term (30 months) - Comparative Biomedical Sciences
Royal College Street, United Kingdom
Application deadline
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The Royal Veterinary College is the largest and longest-established vet school in the English-speaking world and is a college of the University of ...

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