Orion Corporation

Mass spectroscopy specialist for proteins and protein ligand characterisation

2024-06-04
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Are you eager to strengthen our protein MS capabilities at Orion to boost our hit finding and hit characterisation activities in drug discovery?

Description of position

You, as a mass spectroscopy specialist in the Structural Biology and Analytics unit, will be responsible for the setting up and use of techniques like AS-MS, native MS and HDX-MS to study and understand the mode of action of proteins and modulation of protein actions by small molecules.

This is a permanent position and location of the position is in Espoo.

Description of unit

The unit “Structural Biology and Analytics” is a part of the Medicine Design in Innovative Medicines Business Division. Besides the analytical support for all medicinal chemistry activities, the unit focuses on hit finding activities, the understanding of protein modes of action and protein ligand interactions. On site, MS as well as NMR techniques are used to obtain the necessary information. Other techniques like cryoEM or X-ray are used via a strong external network. 

We offer

The position offers an exciting and challenging opportunity for cross-scientific and -cultural collaboration and working in highly motivated teams. You will have the chance to strengthen and build up our expertise of proteins and protein ligand interactions by using & building HDX-MS, AS-MS and native MS capabilities. We have a good working atmosphere based on common values and mutual trust. Please visit our website to find further information about our values and Orion as an employer https://www.orion.fi/en/careers/orion-as-an-employer/.

Requirements

Practical skills with protein-related MS techniques, especially native MS,  HDX-MS or cross-linking techniques, are mandatory to support our activities in the characterisation of protein-ligand interactions and to analyse conformational changes of proteins. The candidate’s special focus will be execution of experiments and data analysis as well as communicating the results to the project team.

The candidate needs to have a good knowledge of protein handling (production beneficial) and must be able to discuss in multidisciplinary project teams the results and the impact of the results on drug design. A basic understanding of biophysical methods is beneficial. A good network with the protein MS community around the world is a big plus.

Additional information

Please send your application incl. salary request and CV by the 4th June 2024. We will start reviewing applications during the application period.

For additional details, please contact Head of Structural Biology and Analytics Josef Messinger tel. +358 50 966 5287 on 20th May at 11.30-14.00  (Finnish time)

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

Orion Corporation operates in more than 30 countries, where we Orionees, 3600 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Job details

Title
Mass spectroscopy specialist for proteins and protein ligand characterisation
Location
Orionintie 1A Espoo, Finland
Published
2024-05-14
Application deadline
2024-06-04 23:59
Job type
Save job

About the employer

We develop, manufacture and market human and veterinary pharmaceuticals and active pharmaceutical ingredients.

Visit the employer page

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