Perception and neural processing of breathlessness and breathlessness relief

The Research Group Health Psychology (https://ppw.kuleuven.be/ogp) at the Faculty of Psychology and Educational Sciences, KU Leuven aims at unravelling how psychological and somatic variables interact in health and disease from a biopsychosocial perspective. Both fundamental and applied research is being conducted to understand how interoceptive sensations are modulated by cognitive, emotional, social and learning processes, thereby contributing to the initiation and maintenance of chronic somatic symptoms, illness and disability. Key words in our group are “dyspnea (breathlessness)”, “pain”, “psychophysiology”, “associative learning”, “interoception” and “symptom perception”. The prevailing research paradigm is the controlled experiment. Measurements typically include a combination of self-reports, psychophysiological/neural responses, clinical outcome measures and/or behavioural data. The ultimate goal is to apply the gathered knowledge in the assessment and early identification of those people at risk, and in the development of customized cognitive-behavioural interventions in the pursuit of prevention and treatment of chronic somatic complaints. Much of the research is conducted in a collaborative, interdisciplinary context. The group has strong connections with other international research groups and with clinical partners such as the University Hospital Leuven.

The present project is a close collaboration with the Research Group for Rehabilitation in Internal Disorders (https://gbiomed.kuleuven.be/english/research/50000743/research/research-units/grid/) and the Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE) (https://research.kuleuven.be/portal/en/unit/50000633) at KU Leuven. Both groups have longstanding expertise in the clinical characterization, treatment and medical follow-up of patients with respiratory disease. In multidisciplinary collaborations these groups are focusing on the effects of pharmacological and non-pharmacological interventions to alter the course of lung disease. Their interest in the consequences of physical inactivity and setting up interventions to successfully enhance physical activity as well as their interest to understand breathlessness from a physiological angle are of particular relevance to the present project.
Website unit

Project

Breathlessness (dyspnea) is the threatening cardinal symptom in many prevalent respiratory diseases such as Chronic Obstructive Pulmonary Disease (COPD) and asthma, but also in other diseases including cancer, cardiac, neuromuscular and psychiatric illnesses. Breathlessness is typically associated with severe disability as well as significant reductions in quality of life in millions of patients worldwide. Currently, treatment options to relieve breathlessness are limited and there is great need for new and improved interventions for the relief of breathlessness. Moreover, the experience of breathlessness and subsequent disabilities are strongly influenced by psychological, social and neural processes, integrating physiological impairments into patients’ subjective perception. However, still little is known about the interrelationships between these different processes.

In this multidisciplinary research project, funded by the Research Foundation - Flanders (FWO), the PhD candidate will examine the interrelationships between neural and psychosocial mechanisms in the perception of breathlessness in healthy individuals and in patients with respiratory disease (e.g., COPD). Specifically, the effects of non-pharmacological interventions for the relief of breathlessness will be studied in combination with neural, physiological and behavioral responses. The PhD student will carry out several studies that aim to assess these topics in experimental laboratory settings as well as in a rehabilitation context. A major focus is the assessment of neural activation patterns related to breathing as measured by evoked potentials in the EEG (128-channel EEG system and/or mobile 32-channel system). Other outcome measures will include exercise tests, self-reports, questionnaires and peripheral psychophysiological responses (e.g., breathing patterns). Apart from the acquisition and statistical analysis of the data, the PhD student will also be responsible for the scientific reporting of the results in international peer-reviewed journals and at scientific conferences. The conducted line of experimental studies, which will be carried out in collaboration with our clinical partners from the University Hospital Leuven, will result in a PhD thesis that will be defended by the end of the research project.

Profile

• You obtained a Master’s Degree in psychology, neuroscience, biomedical science, movement- and rehabilitation science or related field (or will obtain such degree no later than 20/08/2024) with a degree of ‘distinction’
• You have a strong affinity for research on the (neuro)psychology of respiratory disorders/symptoms
• You have a strong interest and/or background in EEG measures, in experimental studies and in psychophysiological measures
• You possess excellent data analytic skills
• You have excellent communicative skills in English (both verbally and academic writing)
• You can verbally communicate in Dutch
• You are a team player who can also work independently
• You have strong organizational skills, are flexible and proactive
• You are not afraid of challenges
• You think critically and have a curious mind
• You are not afraid of being in contact with patients and possess the skills necessary for an empathic and professional interaction with patients

Offer

• Full-time PhD position in a 4-year research project
• Duration of contract: 1-year fulltime PhD position, extendable to 4 years (upon positive evaluation after 1 year)
• Excellent working conditions: https://www.kuleuven.be/personeel/jobsite/en/phd/phd-information#working-conditions
• Professional development via the KU Leuven doctoral school program and YouReCa (https://research.kuleuven.be/en/career/youreca), participation in (inter)national conferences, workshops, teaching, and working in a creative, interdisciplinary environment where cross-fertilization between clinical practice and science is highly valued

Interested?

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