KU Leuven

Postdoc Biochemistry : Applictions of Self-assembling Designer Proteins

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KU Leuven is an autonomous university. It was founded in 1425. It was born of and has grown within the Catholic tradition.

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(ref. BAP-2022-12)

The team of prof. Voet is looking for a biochemist with interest in computational protein design, structural biology, atomic force microscopy and biophysics.

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Over the last decade the field of computational protein design has gained momentum and moved from the design of basic proteins as proof of concepts to protein complexes with useful applications. Among those proof of concept proteins are the monomeric symmetric designer proteins which have been developed the last few years. Given their symmetry, they are the ideal building blocks to create via a so-called bottom-up approach novel materials such as 2D layers and 3D cages or frameworks.
Recently we have developed a novel computationally designer protein family named SAKe which is symmetric in nature yet at the core possess modular loops which, inspired by antibodies, can be evolved/altered to bind to certain binding partners.
The Laboratory of biomolecular modelling and design is part of the Department of Chemistry and is looking for a postdoctoral researcher to continue the work on these SAKe proteins. You will be engineering 2D layers and 3D cages to investigate the formation mechanism, enhance the stability, and develop applications in the field of either enzyme-cascading, biocatalysis, templating of inorganic catalysts, diagnostics and or biopharmaceuticals, targeted drug delivery.
Our laboratory is an interdisciplinary team where computational protein and drug design is combined with protein biophysics, biochemistry and protein crystallography.
This project is embedded in a larger collaboration with the group of Prof Steven De Feyter, also at the department of chemistry to perform Atomic Force Microscopy and the group of Prof. Vitor Pinheiro (REGA institute, KU Leuven). Furthermore our laboratory is part of the PharmAbs consortium which develops pharmaceuticals and diagnostic antibodies.


It is important to have an independent problem-solving academic mindset. Publications are a high priority. Your profile should include:

  • Recent (max 4 year) Ph.D. in Biochemistry with excellent publication record
  • Experience with protein production and characterisation
  • Experience with Atomic force microscopy
  • Experience with other biophysics methods is an asset
  • Excellent communicator in English, written and verbal
  • Social and result-driven personality
  • Ability to work and thrive in a collaborative team-orientated environment


  • The opportunity to be part of a multidisciplinary international  research lab
  • Access to state-of-the-art infrastructure including core facilities
  • A dynamic working environment and a stimulating scientific surrounding in a young, enthusiastic, motivated team, where postdoc can work on their own trajectory
  • A 3-year position, with an initial contract of 1 year.


For more information please contact Prof. dr. Arnout Voet, tel.: +32 16 32 44 96, mail: arnout.voet@kuleuven.be.

You can apply for this job no later than February 28, 2022 via the online application tool

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

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Postdoc Biochemistry : Applictions of Self-assembling Designer Proteins
Oude Markt 13 Leuven, Belgium
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