Construction and interrogation of neural circuits with single cell resolution on high-density MEA chips
What you will do
Neurodegenerative diseases such as Parkinson’s Disease cannot be studied in situ in a living patient, and the much-studied transgenic animal models have not demonstrated to deliver on their promise of bringing a cure. For many of these diseases, there is no or only symptomatic treatment available. Radically novel approaches are needed to shed new light on mechanisms and pathways behind these complex disorders.
We are building neural microcircuits on high-density CMOS microelectrode array chips that represent the affected brain circuit, by using the patient’s own cells. By single-cell electroporation using the chip’s electrodes, we introduce molecules to drive differentiation of stem or primary cells towards neuronal sub-types. The same electrodes are used to record electrophysiological (e-Phys) data from the neural circuit, thereby mapping novel phenotypes of disease. Additional assays are being developed with complementing cell types, such as astrocytes and microglia. The microcircuit model will be further developed and improved by moving from 2D to 3D cell assemblies. Finally, the e-Phys data will be complemented with transcriptome data and linked to the clinical background of the patient to improve the phenotype and stratify the patient population.
In this postdoc, your main activities will be:
You will be working in a multidisciplinary and dynamic team. The project is part of Mission Lucidity2, a unique constellation of engineers, neuroscientists, and clinicians, with the aim to decode brain disease.
What we do for you
We offer you the opportunity to join one of the world’s premier research centers in nanotechnology at its headquarters in Leuven, Belgium. With your talent, passion and expertise, you’ll become part of a team that makes the impossible possible. Together, we shape the technology that will determine the society of tomorrow.
We are proud of our open, multicultural, and informal working environment with ample possibilities to take initiative and show responsibility. We commit to supporting and guiding you in this process; not only with words but also with tangible actions. Through imec.academy, 'our corporate university', we actively invest in your development to further your technical and personal growth.
We are aware that your valuable contribution makes imec a top player in its field. Your energy and commitment are therefore appreciated by means of a competitive scholarship.
Who you are
This postdoctoral position is funded by imec through KU Leuven. Because of the specific financing statute which targets international mobility for postdocs, only candidates who did not stay or work/study in Belgium for more than 24 months in the past 3 years can be considered for the position (short stays such as holiday, participation in conferences, etc. are not taken into account).
Apply online at www.imec.be/jobs.
Development of novel applications using transducers, sensors and actuators using MEMS technology What you will do Within imec’s Sensor and Actuator Technology department, our team’s research activities focus on the development of novel applica...
Researcher on development of platform technology and testing of assays related to organ on chip program and cellular/tissue technology What you will do You will be part of a multi-disciplinary team that works towards the development of novel micro...
Participate in the development of next generation batteries What you will do Lithium-ion is the technology of choice for rechargeable battery applications as the Li-ion electrode chemistries provide the highest volumetric and gravimetric energy de...
Take an active role in the development of next-generation conversion and storage technologies What you will do You will be part of imec’s energy department in which you will take an active role in the development of next-generation conversion an...
Gain eternal fame and have lots of fun What you will do Are you a highly motivated researcher with a strong background in analog, mixed-signal, RF, and/or mm-wave IC design? Is your ambition to work in a diverse research environment amongst some o...
Imec is the world-leading research and innovation hub in nanoelectronics and digital technologies. The combination of our widely acclaimed leadersh...Visit the employer page