Within the EU project “Identification and Management of Patients at Risk – Outcome and Vascular Events in Peritoneal Dialysis” (IMPROVE-PD), the Research Group of Pediatric Nephrology of the Heidelberg University will host an
Early Stage Researcher in Biomedical Science
Description of the ESR project
Objectives: The ESR will digitally analyse peritoneal and arterial specimens from healthy, uremic and PD treated children and adults from Heidelberg, Cardiff, and Madrid biobanks. Findings will be related to PD treatment modalities, clinical disease spectrum and inflammatory complications. Molecular mechanisms will be assessed by whole exome profiling, and (in secondments) by proteomics, miRNA sequencing, and (omental) metabolomics. Key findings will be validated in independent cohorts, compared with findings in HD patients and cross-validated in experimental settings. The human ex vivo findings will also serve for validation of experimental data obtained in other groups of the consortium and provide molecular patterns to interact with by development of novel PD fluids.
Expected Results: Molecular characterization/pathway identification of uraemia, and PD induced tissue damage and vascular disease. The project will provide a data warehouse which will allow for validation of present and future experimental PD studies in humans and define pathomechanisms, novel PD fluids should interfere with locally and with regard to systemic cardiovascular disease (CVD).
About the Group
The Pediatric Nephrology Group and cooperating partners offer all state of the art research and training facilities, a unique training is provided. The group coordinates the Int. Pediatric Dialysis Network, the Int. Pediatric PD Biobank, and the ESCAPE, 4C, PodoNet and EURenOmics consortia. The central bio repository holds 44000 aliquots from 3000 children with renal diseases and 600 peritoneal specimens. Access to respective adult biobanks is available in Heidelberg and in cooperating centres.
The ESR will be placed in a unique interdisciplinary network of PhD and postdoc fellows in Heidelberg and cooperating centres. She/he should be highly interested in histopathology and in-depth molecular tissue analyses and experimental PD research with close clinical background, and enthusiastically advance skills and knowledge to substantially contribute in the field of PD.
Candidates can submit their application forms up to 10 June 2019 to email@example.com. For more detailed information on the project and the application procedure please visit the IMPROVE-PD website (www.improvepd.eu) or contact ClausPeter.Schmitt@med.uni-heidelberg.de or Maria.Bartosova@med.uni-heidelberg.de. The project is limited to 36 months but an extension of the employment is intended.
Please refrain from using application folders and do not send original documents, as these are not returned but destroyed after completion of the procedure in accordance with data protection. We stand for equal opportunities. Handicapped applicants will be given preference if equally qualified.Continue reading
|Title||Early Stage Researcher in Biomedical Science|
|Job location||Grabengasse 1, 69117 Heidelberg|
|Published||March 4, 2019|
|Application deadline||June 10, 2019|
|Job types||PhD  |
|Fields||Biomedicine,   Clinical Sciences,   Pathology,   Molecular Biology,   Histology,   Molecular Medicine  |