Last application date Jul 02, 2023 00:00
Department GE35 - Department of Internal Medicine and Pediatrics
Contract Limited duration
Degree Master degree in Biochemistry & Biotechnology, Bioscience engineering, or equivalent, completed before the start date of the position, with excellent grades.
Occupancy rate 100%
Vacancy type Research staff
The current PhD position is available for a highly motivated candidate to work on a granted multi-disciplinary project within the research group of Prof. Mo Lamkanfi, and involving several other research groups at Ghent University. The main aims of the PhD project is to define molecular mechanisms regulating cell death induction by Gasdermin family members and to address their role in cancer and autoinflammatory diseases. In this regard, the PhD student will setup experiments using cutting-edge CRISPR-Cas9 genome-wide screening approaches and retroviral transduction technologies to discover and functionally knockout or tag potential genes that modulate lytic cell death activation in primary hematopoietic and epithelial cells of human and murine origin. In this project, we will also make use of advanced confocal microscopy, flow cytometry and mouse transgenesis to understand how lytic cell death contributes to inflammatory and neoplastic pathology.
Type of employment
PhD candidate researcher: Full-time, fixed-term appointment for initially 1 year, yearly renewable after positive evaluation up to 4 years. Intended starting date: 1st of June 2023 (later start dates are also possible in mutual agreement). A competitive salary including benefits is offered, salary levels account for years of professional experience. Ghent University is an equal opportunity employer.
About the lab
The research team of Prof. Mo Lamkanfi, also called the Laboratory of Medical Immunology, has a longstanding interest in understanding inflammasome signalling and lytic cell death pathways that contribute majorly to chronic inflammatory diseases and play a crucial role in host defense against microbial pathogens. The Lamkanfi lab currently has a vacancy for a highly motivated PhD student to investigate novel regulatory pathways and the functional impact of pyroptosis and other lytic cell death mechanisms in inflammatory and neoplastic diseases. The research group has at its disposal state-of-the-art research facilities and is integrated in the Medical Research Building 2 facilities of the Ghent University Hospital Campus in Ghent, Belgium. Within close proximity of the academic hospital, the research group aims to translate the fundamental knowledge generated into the design of novel therapeutic and diagnostic tools (e.g. PMID: 32312770; PMID: 31525186).
To apply or for more information please contact Prof. dr. Mo Lamkanfi (Mohamed.Lamkanfi@ugent.be).
Please include a single pdf in your application that combines the following elements:
The position is immediately available. Applications are welcome until the position is filled. The first review of applications will start immediately. A shortlist of applicants will be selected and invited for interviews on a rolling basis until the position is filled.
As Ghent University maintains equal opportunities and a diversity policy, everyone is encouraged to apply for this position.
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