European Synchrotron Radiation Facility (ESRF)

Postdoctoral fellow on ID29, the serial and time-resolved macromolecular crystallography beamline

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The European Synchrotron, the ESRF, is an international research centre based in Grenoble, France.

Through its innovative engineering, pioneering scientific vision and a strong commitment from its 700 staff members, the ESRF is recognised as one of the top research facilities worldwide. Its particle accelerator produces intense X-ray beams that are used by thousands of scientists each year for experiments in diverse fields such as biology, medicine, environmental sciences, cultural heritage, materials science, and physics.

Supported by 21 countries, the ESRF is an equal opportunity employer and encourages diversity.

As part of the Extremely Brilliant Source facility upgrade (, the ESRF has constructed a new beamline for serial and time-resolved macromolecular crystallography (TR-     SSX) experiments at room temperature. The new ID29 beamline delivers an unprecedented flux density, allowing the recording of diffraction data from micron-sized samples in a few microseconds, and is equipped with a next generation diffractometer and a Jungfrau detector. Beamline operations are supported by a dedicated sample preparation laboratory where the most suitable crystal delivery systems such as injectors, fixed targets and microfluidic devices will be prepared and characterised prior to experiments. In addition, a dedicated instrument, the TR-icOS (time-resolved in crystallo optical spectroscopy) setup has been specifically developed to help characterize time delays and titrate laser pump energy in pump-probe diffraction experiments occurring on ID29.

The postdoctoral position available will focus on developing novel data collection methods for TR-SSX and TR-icOS, and characterise radiation effects at high X-ray or visible photon flux densities. The selected candidate will also take part in the development and the commissioning of the new ID29, performing state-of-the art experiments at the new end-station.

As for all post-doctoral researchers in the Structural Biology Group, the successful candidate will participate in in-house research programmes, will contribute to the operation of beamlines and will provide support to external users as local contact.

Further information may be obtained from Daniele de Sanctis ( and Antoine Royant (

- PhD in chemistry, physics, biophysics, biology or closely related science obtained less than 3 years ago

- A strong background in X-ray crystallography, optical spectroscopy and serial crystallography is desirable

- A strong interest in new method development

- Ability to interact with multi-disciplinary staff and facility users

- Proficiency in English (working language at the ESRF)

Contract of 18 months, renewable for a further 6 or 18-month period.

What we offer:

- Be inspired by our innovative research institute, with an international workforce from 38 different countries

- Collaborate with global experts on real-world science

- Come and live in a vibrant city, in the heart of the Alps, and Europe's Green Capital 2022

- Enjoy a workplace designed to support your quality of life

- Benefit from our competitive compensation and allowances package, including financial support for your relocation to Grenoble For further information on employment terms and conditions, please refer to

The ESRF is an equal opportunity employer and encourages applications from disabled persons.

If you are interested in this position, please apply online at

Job details

Postdoctoral fellow on ID29, the serial and time-resolved macromolecular crystallography beamline
71 avenue des Martyrs Grenoble, France
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About the employer

The ESRF is an X-ray light source for Europe. It is located in Grenoble, France, and supported and shared by 20 countries.

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