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The deMello Group in the Department of Chemistry and Applied Biosciences at ETH Zürich, a world-leading center for the development of novel microfluidic technologies, is looking for a motivated PhD student to develop state-of-the-art microfluidic and imaging techniques for identifying inhibitors of Alzheimer’s disease.
Alzheimer's disease (AD) remains a global challenge, lacking effective treatments. Current drugs offer limited benefits, highlighting an urgent need for novel therapeutic strategies. A primary factor limiting the identification of new drug candidates is the dearth of robust, time- and cost-effective screening methods. High-throughput screening methods are critical for drug discovery but are commonly unable to mimic the brain microenvironment or provide detailed mechanistic insights. Microfluidics offers a powerful experimental platform able to recreate physiologically relevant conditions and perform rapid and cost-effective screening of chemical libraries.
The aim of this project is to develop microfluidic platforms able to identify small molecule inhibitors that target AD. Specifically, a combination of microfluidics, time-resolved and super -resolution fluorescence imaging, and high-throughput screening will be used to accelerate the discovery of novel therapeutics under conditions that mimic the physiological environment of cell membranes.
Key Responsibilities:
The successful candidate should hold:
ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.
We look forward to receiving online applications that include:
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Specific questions regarding the position can be directed to Dr Stavros Stavrakis, by email (stavros.stavrakis@chem.ethz.ch)
ETH Zürich is well known for its excellent education, ground-breaking fundamental research and for implementing its results directly into practice.
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