The Ecole polytechnique fédérale de Lausanne (EPFL) is one of the most dynamic university campuses in Europe and ranks among the top 20 universities worldwide. The EPFL employs 6,000 people supporting the three main missions of the institutions: education, research and innovation. The EPFL campus offers an exceptional working environment at the heart of a community of 16,000 people, including over 10,000 students and 3,500 researchers from 120 different countries.
A postdoctoral position is available in the Schoonjans Lab at the Laboratory of Metabolic Signaling in the Institute of Bioengineering of the École Polytechnique Fédérale de Lausanne (EPFL).
Your mission :
Our laboratory is a dynamic multi-disciplinary research lab dedicated to developing technology and knowledge oriented at dissecting the multifaceted connections between the gut and the liver in the enterohepatic physiological system. By investigating the molecular basis by which nutrient-derived metabolites, including bile acids and other signaling molecules, act as controllers of tissue homeostasis, your mission will be part of a larger scope in the laboratory to identify novel mechanisms and strategies to target a wide range of chronic disorders, including metabolic diseases (obesity, diabetes and non-alcoholic fatty liver disease) and cancer.
Main duties and responsibilities include :
The project focuses on the liver-gut axis, a system specialized in nutrient sensing and processing that plays a major role in the regulation of whole-body physiology. These two organs communicate extensively via the biliary tract, portal vein, and systemic mediators. Intestinal factors regulate bile acid synthesis, glucose and lipid metabolism in the liver whereas hepatic molecules, such as bile acids, influence intestinal homeostasis. The project covers both ways of this communication system with particular emphasis on metabolic regulation of adult epithelial stem cells. By investigating how nutrient-derived molecules trigger adaptive responses in the enterohepatic system, the project aims at dissecting the regulation of hepatic progenitor metabolism and function by the intestine and the gut microbiome. Conversely, we are interested in understanding how liver-produced bile acids can control intestinal renewal under normal and pathological conditions such as diet-induced obesity and cancer. The project is strongly oriented toward the design of stem cell-based regenerative medicine therapies as innovative approach for the treatment of different metabolic diseases. We will use state of the art in vivo approaches involving diet-induced and genetically modified animal models as well as mouse- and human-derived intestine and liver 3D organoid culture systems. These organoids will be used for genetic manipulation, imaging, co-cultures, and omics analysis in order to investigate fundamental questions related to the liver-gut axis and its regulation by signaling molecules. Moreover, intestine and liver organoids will be engineered to model metabolic dysfunctions, such as non-alcoholic fatty liver disease and intestinal cancers, and used for high throughput drug screening.
Your profile :
We are looking for a highly motivated, successful and enthusiastic candidate with a PhD in biomedicine or related area. We expect the candidate to have a competitive scientific background and an excellent record of primary author publications. Previous experience working with mouse models and primary cultures as well as stem cell/tumor biology would be an advantage. A solid background in cell and molecular biology methods and bioinformatics is mandatory. The applicant is expected to have excellent communication and interpersonal skills and to be proficient in both spoken and written English.
We offer :
Start date :
As of 01.02.2020
Term of employment :
Work rate :
1 year, renewable
Please apply on line on the following link: https://recruiting.epfl.ch/Vacancies/1139/Description/2Continue reading
|Title||Postdoctoral position in metabolite sensing and adult stem cell homeostasis|
|Employer||EPFL École polytechnique fédérale de Lausanne|
|Job location||Route Cantonale, 1015 Lausanne|
|Published||December 4, 2019|
|Job types||Postdoc  |
|Fields||Biomedical Engineering,   Biomedicine,   Cancer Research,   Clinical Sciences,   Bioinformatics,   Molecular Biology,   Genetics,   Cell Biology,   Bioengineering,    and 1 more. Regenerative Medicine  |