We are seeking an enthusiastic and energetic candidate for a Technical Assistant in Mass Spectrometry position to join our dynamic Proteomics Team at the Molecular Discovery Platform of CeMM. Interested candidates should have a background in analytical sciences or life sciences. Knowledge of nano LC-MS, HPLC-MS, or GC-MS would be a plus but is not required. The main duties in this position include proteomics sample preparation, as well as operation, maintenance and troubleshooting of state-of-the-art LC-MS instrumentation, plus an active engagement in scientific projects at CeMM. General laboratory management and organizational skills are also part of the job requirements. To work successfully in our international team excellent English skills, communication talent and good computer skills are a prerequisite. Ideally, you have a basic understanding of protein chemistry and/or biochemistry. Knowledge in some scientific, graphic, and statistical software as well as mass spectrometry specific software would be an additional asset.
Tasks and responsibilities
The Molecular Discovery Platform
The CeMM Molecular Discovery Platform uses a technology-driven approach to empower the discovery and characterization of such bioactive molecules, including proteins, metabolites, and novel synthetic compounds. These three classes of molecules are also the focus of the three modules that constitute the CeMM Molecular Discovery Platform — Proteomics, Metabolomics, and Chemical Screening. Using the latest technologies and state-of-the art instrumentation, we maximize coverage to biomolecules and enable data generation from minimal biological sample amounts. The platform, with its three sub-facilities, provides services to all groups at CeMM as well as to external customers and thereby intends to contribute initial starting points towards discovering the therapies of the future.
The Proteomics Team
The Proteomics Team provides services on “state-of-the-art” Mass spectrometry-based proteomics applications to support scientific research groups in basic and translational research. The special design of the MS lab guarantees our customers the highest standards for “high resolution accurate mass” (HRAM) LC-MS instrumentation of the Q Exactive and Fusion Lumos Orbitrap series with staﬀ maintaining and operating the systems at a constantly high level.
The mass spectrometry laboratory space was designed to the highest standards when the group relocated to the new CeMM building on the medical campus. To operate under optimal conditions in an analytically suitable environment, each machine resides in an individual cubicle that is maintained at constant temperature and humidity. Minimal downtime is assured via remote surveillance whereby the performance of the systems can be consistently monitored. Diﬀerent proteomics work-flows are well established in the facility including protein identification and profiling, quantitative expression proteomics, quantitative phospho-proteomics, Immunoprecipitation and Aﬃnity Purification Mass Spectrometry (IP-MS/AP-MS), as well as targeted Parallel Reaction Monitoring (tPRM). Standard Operation Procedures for Data Dependent Acquisition (DDA), Data Independent Acquisition (DIA), and multiplexed isobaric tagging (TMT) are routinely performed. The state-of-the-art machine park and methodology allows for a robust investigation of the human proteome in diﬀerent cell types and biological matrices.
About the Institute
The mission of CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences is to achieve maximum scientific innovation in molecular medicine to improve healthcare. At CeMM, an international and creative team of scientists and medical doctors pursues free-minded basic life science research in a large and vibrant hospital environment of outstanding medical tradition and practice. CeMM’s research is based on post-genomic technologies and focuses on societally important diseases, such as immune disorders and infections, cancer and metabolic disorders. CeMM operates in a unique mode of super-cooperation, connecting biology with medicine, experiments with computation, discovery with translation, and science with society and the arts. CeMM discovers and develops technologies to explore human biology with the purpose of defeating disease at its roots. Because Science is our Medicine! CeMM trains a modern blend of biomedical scientists and is located at the campus of the General Hospital and the Medical University of Vienna. More than 150 people from 45 nationalities are working at CeMM. CeMM promotes equal opportunity and harbors a mix of diﬀerent talents, backgrounds, competences, and interests.
Please apply online (https://cemm.jobbase.io/job/qftpt648) with cover letter, CV and contact details of 2 referees. Any application received by 31st August 2022 will be considered. Applications will be reviewed on a rolling basis.
Position type Full-time employee
Start of work 01.10.2022
Responsible Memo Mokhles
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