RESEARCHER PROFILE: PhD / R1: First stage Researcher
RESEARCH FIELD(S)1: Physics
MAIN SUB RESEARCH FIELD OR DISCIPLINES1: Physics
JOB /OFFER DESCRIPTION
Optical tweezers offer a versatile approach to manipulate living cells and other micron-sized objects with minimal invasiveness. However, due to the diffraction limit, objects with sizes below 100 nm are nearly impossible to trap using conventional microscopes. To overcome this limitation, nanophotonics allows to concentrate light well below the diffraction limit. The nano-optical tweezers enable efficient trapping of nanoscale objects that would otherwise be too small or too transparent to be manipulated using conventional optical tweezers. However the plasmonic nanotweezers using optical resonances in metal nanogaps come with their own issues: the fabrication is complex and expensive, the control and reproducibility is often poor for gap sizes below 20 nm, and the range of action is limited, requiring long waiting times of several minutes to trap a particle.
A paradigm change is needed to overcome the limitations in the manipulation of nano-objects. Here we propose to use thermal gradient forces instead of optical gradient forces. Temperature gradients at the micro/nanoscale can induce forces which will be exploited in this PhD project to trap single nano-objects as small as 5 nm with an action range larger than 500 nm.
Jerome Wenger’s group has acquired a wide expertise in the nanoscale control of light fields in plasmonic nanostructures and its application to enhance fluorescence spectroscopy applications. For our next project we will focus on opto-thermal trapping of single nanoobjects (nanoparticles, quantum dots, proteins with fluorescent tags) to enhance spectroscopy applications on single nano-objects.
Thanks to the large range of thermal forces, a single nanoparticle can be trapped within a few seconds after the infrared beam is switched on, even at sub-nanomolar concentrations. We target a localization accuracy sufficiently below the spatial resolution of the optical microscopes used for the different applications. As nanometer gaps are not required, the fabrication will remain cost-effective and easily scalable for highly parallel operation.
The manipulation of single nano-objects (nanoparticles, quantum dots, proteins, viruses…) is a key element for various areas of nanosciences, multiplying the potential impact of optically-controlled thermal tweezers. Manipulating single nano-objects is highly cross-disciplinary at the interface between photonics, biophysics and nanotechnology. This innovative approach will enable the exploration of a brand new territory of optical tweezers down to the single molecule level. The outcomes of this PhD project will further advance the fields of nano-optical trapping, nanophotonics and single-molecule biophysics, and will benefit a wide range of sensing applications.
The Institut Fresnel is a research state laboratory based in Marseille / France, devoted to research and higher education with affiliation to both CNRS and Aix Marseille University. Institut Fresnel is seeking to recruit talented, enthusiastic young scientists who are highly motivated to boost their research career in the areas of nanosciences, biosensing, and nano/biotechnologies.
The PhD fellowship is offered for a period up to three years. Extensions will be possible based on context and performance. A PhD degree from Aix Marseille University will be granted after successful completion of the PhD research.
TYPE OF CONTRACT: TEMPORARY / JOB STATUS: FULL TIME / HOURS PER WEEK: 38
APPLICATION DEADLINE: 31/03/2024
ENVISAGED STARTING DATE: 01/10/2024
ENVISAGED DURATION: 36 months
JOB NOT FUNDED THROUGH AN EU RESEARCH FRAMEWORK PROGRAMME
WORK LOCATION(S): Institut Fresnel, faculté des sciences de St Jerome, 52 avenue Escadrille Normandie Niémen, 13013 Marseille, France
WHAT WE OFFER:
Additional information: The Euraxess Center of Aix-Marseille Université informs foreign visiting professors, researchers, postdoc and PhD candidates about the administrative steps to be undertaken prior to arrival at AMU and the various practical formalities to be completed once in France: visas and entry requirements, insurance, help finding accommodation, support in opening a bank account, etc. More information on AMU EURAXESS Portal
QUALIFICATIONS, REQUIRED RESEARCH FIELDS, REQUIRED EDUCATION LEVEL, PROFESSIONAL SKILLS, OTHER RESEARCH REQUIREMENTS
To apply for a PhD fellowship, candidates must hold an internationally-recognized Master-equivalent degree in physics, nanosciences or engineering. Experience in experimental and/or theoretical research on nano-optics and/or biophotonics will be highly appreciated, but is not mandatory. No restrictions of citizenship apply to the PhD fellowship.
Soft skills: Strong motivation for optics, curiosity for nanosciences, English for science, autonomy, analytical and critical thinking, writing skills, presentation skills
REQUESTED DOCUMENTS OF APPLICATION, ELIGIBILITY CRITERIA, SELECTION PROCESS
Suitable candidates are requested to submit:
HOW TO APPLY: Jerome.firstname.lastname@example.org
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